Organic Letters · 2015 · 54 citations · 59 references
Natural SciencesChemistryMedicinal ChemistryCatalysisOrganic ChemistrySynthetic Medicinal ChemistryCoordination ChemistryHeterocycle SynthesisMetal CatalysisMicrowave-assisted SynthesisOrganic SynthesisMicrowave-assisted C-h FunctionalizationMicrowave-assisted CatalysisMicrowave-assisted Organic SynthesisMicrowave-assisted Preparation
A microwave-assisted method for the palladium-catalyzed direct arylation of quinazolin-4-one has been developed under copper-assistance. This method is applicable to a wide range of aryl iodides and substituted (2H)-quinazolin-4-ones. This protocol provides a simple and efficient way to synthesize biologically relevant 2-arylquinazolin-4-one backbones.
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