Analysis of Expression of Matrix Metalloproteinases and Tissue Inhibitors of Metalloproteinases in Human Ciliary Body after Latanoprost

Abstract

The transcription of the genes for MMP-3 and -17 is increased by latanoprost treatment. MMP-9 is present after latanoprost treatment and may also mediate ECM changes. TIMP-3 is upregulated and may compensate for the increase in MMPs. These coordinated changes could be expected to mediate the latanoprost-induced alteration of ECM in the ciliary body.