Characterizing and Predicting Amphotericin B‐Associated Nephrotoxicity in Bone Marrow or Peripheral Blood Stem Cell Transplant Recipients

Abstract

Recipients of a BMT or PBSCT who have multiple myeloma and are receiving cyclosporine or multiple nephrotoxic drugs at the start of amphotericin B therapy should be considered at high risk for developing amphotericin B-associated nephrotoxicity. Also, because amphotericin B-associated nephrotoxicity develops rapidly, clinicians should be aware of the rapid changes in serum creatinine and electrolyte levels that can occur.