American Journal of Lifestyle Medicine · 2014 · 14 citations · 68 references
MedicineBehavioral SciencesNutritionEating DisordersMetabolic PhysiologyPathophysiologyAdipose TissueBinge-eating DisorderDisordered EatingEating BehaviorsMetabolic DiseaseWeight ManagementBody Composition MeasurementDisorderEnvironmental Determinants Of ObesityGenetic Susceptibility To ObesityMetabolic Disease EtiologyObesity PhysiologyObesogenic Environment
The study of obesity lends itself to difficulties not only due to our imprecise ability to measure body composition, food consumption, and physical activity but also, even more important, due to complexities involved in defining and conceptualizing obesity. For centuries, obesity has been considered a disease, although researchers and clinicians cannot agree on definitions of "disease" or, if it is one, whether obesity is a disease of metabolism, inflammation, brown fat, chronobiology, the blood-brain barrier, the right brain, or even of infectious origin. The concept of "obesity" as a disease remains controversial to some because not everyone who has excess adipose tissue has any evidence of disease. Obesity, though, has also been considered a sin, a crime against society, an aesthetic crime, a self-inflicted disability, an example of body diversity, a failure in the regulation of energy balance, an appropriate or even inappropriate adaptation to our increasingly obesogenic environment, a genetic disorder, and a psychological/behavioral disorder of overeating involving self-regulation or even addiction. Five major paradigms-medical, sociocultural, evolutionary, environmental, and psychological/behavioral, all with their own subcategorical models-have been identified. All 5 paradigms are required because we are dealing not with "obesity" but with a plurality, the "obesities."
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Dilemmas in a general theory of planning
Horst W. J. Rittel, Melvin M. Webber · Policy Sciences · 1973 · 15.3K citations · Full text
An obesity-associated gut microbiome with increased capacity for energy harvest
Peter J. Turnbaugh, Ruth E. Ley, Michael A. Mahowald et al. · Nature · 2006 · 12.4K citations
Gut Microbiota from Twins Discordant for Obesity Modulate Metabolism in Mice
Vanessa K. Ridaura, Jeremiah J. Faith, Federico E. Rey et al. · Science · 2013 · 3.8K citations
Life Sciences, Biology, Microbiology +17