Activation of Nuclear Factor kappa B and Severe Hepatic Necrosis May Mediate Systemic Inflammation in Choline-deficient/Ethionine-supplemented Diet-induced Pancreatitis

Abstract

Choline-deficient/ethionine-supplemented diet-induced SAP is accompanied with hepatocellular apoptosis and eventual necrosis. This injury is associated with the hepatic NF-kappaB activation leading to the production of NF-kappaB-dependent cytokines and chemokines in the liver, which may mediate the lung injury.