EFFECTS OF ANTERIOR PITUITARY PREPARATIONS IN EXPERIMENTAL PANCREATIC DIABETES

Abstract

WHETHER OR NOT the diabetogenic effects of anterior pituitary preparations and the effect upon growth are related has interested several observers. Shipley and Long (i) and Young (a) found that fractions which had the greatest effect upon growth were also the most diabetogenic. Young (3) considered the possibility that only one pituitary factor is involved, and that the response of the pancreas to it could determine whether nitrogen storage or diabetogenic effects would result. In this connection he cited Mirsky’s experiments (4), which suggest that growth preparations may influence protein metabolism by way of the pancreas. Several studies in this laboratory have dealt with the metabolic effects of anterior pituitary growth preparations in normal, phlorhizinized, and depancreatized bitches. Single large injections were given to fed animals. The normal ones showed only “growth effects,” for example, rise in weight and marked nitrogen storage.