Pharmacokinetics of oxfendazole in goats: a comparison with sheep

Abstract

In goats, there was a linear correlation of area under the plasma concentration-time curve (AUC) with dose in the range 0-20 mg/kg as single dosages of oxfendazole (OFZ). The bioavailability of OFZ after oral administration was lower in goats than in sheep. The repetition of three administrations at 24 h intervals produced significant increase in the AUC in comparison with a single administration equivalent to the total dosage (1 X 5.0 and 3 X 1.7 mg/kg). Infection with O. circumcincta produced a 33% decrease in the bioavailability of OFZ.