Enhanced learning and memory of normal young rats by repeated oral administration of Krill Phosphatidylserine

Abstract

Treatment with Krill-PS (100 mg/kg) produced a significant improvement of the escape latency to find the platform in the MWM at the 3rd day compared to that of the normal group. In the retention test, the Krill-PS100 group showed markedly increased time spent, distance, and crossing number around the platform compared to that of the normal group. Consistent with the behavioral data, the Krill-PS 100 group was significantly enhanced the BDNF and IGF immuno-positive neurons in the hippocampal CA1. In the PET analysis, the glucose uptake of the Krill-PS-treated groups was increased in the frontal lobe and hippocampus. These results suggest that repeated Krill-PS treatment may be useful for improving the cognitive function via regulation of neuronal growth factor activity.