Forward, Relaxed, and Reverse Selection for Reduced and Enhanced Sensitivity to Ethanol's Locomotor Stimulant Effects in Mice

Abstract

Residual heterozygosity persisted at trait-relevant loci even at the selection plateau, possibly due to heterosis, natural selection favoring heterozygosity, or epistatic phenomena involving differences in the sets of genes regulating the high- versus low-sensitivity traits. They also suggest that some common genes influence sensitivity to ethanol's locomotor stimulant and sedative effects.