Cardiac Sodium Channel ( <i>SCN5A</i> ) Variants Associated with Atrial Fibrillation

Abstract

Mutations or rare variants in SCN5A may predispose patients with or without underlying heart disease to AF. The findings of the present study expand the clinical spectrum of disorders of the cardiac sodium channel to include AF and represent important progress toward molecular phenotyping and directed rather than empirical therapy for this common arrhythmia.