Concepedia

Efficacy of DHMEQ, a NF-κB Inhibitor, in Islet Transplantation

Daisuke Kuraya, Masaaki Watanabe, Yasuyuki Koshizuka, Masaomi Ogura, Tadashi Yoshida, Yoh Asahi, Hirofumi Kamachi, Takashi Nakamura, Hideyoshi Harashima, Michitaka Ozaki,

Transplantation · 2013 · 24 citations · 39 references

DOI

Abstract

Inhibition of NF-κB activation by DHMEQ after PITx reduces the HMGB1-triggered proinflammatory responses and results in engraftment of transplanted islets even with fewer islet grafts.

References

39

Islet Transplantation in Seven Patients with Type 1 Diabetes Mellitus Using a Glucocorticoid-Free Immunosuppressive Regimen

A.M. James Shapiro, Jonathan R.T. Lakey, Edmond A. Ryan et al. · New England Journal of Medicine · 2000 · 5.2K citations · Full text

Release of chromatin protein HMGB1 by necrotic cells triggers inflammation

Paola Scaffidi, Tom Misteli, Marco E. Bianchi · Nature · 2002 · 4.1K citations

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IKKα limits macrophage NF-κB activation and contributes to the resolution of inflammation

Toby Lawrence, Magali Bébien, George Y. Liu et al. · Nature · 2005 · 619 citations

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Production of tissue factor by pancreatic islet cells as a trigger of detrimental thrombotic reactions in clinical islet transplantation

Lisa Moberg, H Johansson, Agneta Lukinius et al. · The Lancet · 2002 · 558 citations

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Release of High Mobility Group Box 1 by Dendritic Cells Controls T Cell Activation via the Receptor for Advanced Glycation End Products

Ingrid E. Dumitriu, Paramita Baruah, Barbara Valentinis et al. · The Journal of Immunology · 2005 · 497 citations · Full text