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CHOLINERGIC AND ADRENERGIC COMPONENTS IN THE NEUROHUMORAL CONTROL OF THE RELEASE OF LH IN THE RABBIT
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1949
Year
Pituitary StalkFemale Reproductive SystemFemale Reproductive FunctionReproductive BiologyEmbryologyReproductive EndocrinologyReproductive PhysiologyAdrenal GlandPituitary GlandNeuroendocrine MechanismReproductive MedicinePublic HealthAnimal PhysiologyNeuropharmacologyElectrical Stimulation ExperimentsNervous SystemEndocrinologyPharmacologyDevelopmental BiologyNeurophysiologyNeuroanatomyPhysiologyUterine ReceptivityReceptor BiologyNeuroscienceCentral Nervous SystemMedicineReproductive HormoneGonadotropin Biology
introduction The nervous system, in species like the rabbit which do not ovulate spontaneously, controls ovulation by stimulating the anterior lobe of the hypophysis to release lutenizing hormone; LH in turn (alone or in combination with FSH) activates maturation and rupture of the ovarian follicles (Hisaw, 1947). The nature of the mechanism by which the central nervous system exerts its influence on the hypophysis has been the subject of numerous investigations including those of Markee, Sawyer, and Hollinshead (1946–1948). Electrical stimulation experiments by these authors (1946) gave evidence that hypothalamic control of the anterior lobe, which almost certainly involves the pituitary stalk (Brooks, 1940), is not exerted via nerve fibers ending in the pars distalis. The results indicated, rather, that a humoral link, such as the hypophyseal portal system (Wislocki and King, 1936; Green and Harris, 1947), might transport a chemical mediator capable of stimulating the electrically-inexcitable gland cells.