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Lipophilic conjugates of methotrexate with short-chain alkylamino acids as DHFR inhibitors. Synthesis, biological evaluation, and molecular modeling

Molecular PharmacologyMedicinal ChemistryPharmaceutical ScienceShort-chain Alkylamino AcidsBiochemistryMedicineNatural SciencesRational Drug DesignDhfr InhibitorsDrug DevelopmentChemical BiologyPharmacologyPharmaceutical ChemistrySynthetic ChemistryDrug DiscoveryLipophilic Conjugates