Organic Letters · 2010 · 122 citations · 30 references
Natural SciencesChemical EngineeringChemistryCatalysisOrganic ChemistryCross-coupling ReactionsHeterocycle SynthesisHeterocyclic ChemistryHeterocyclic CompoundsMetal CatalysisOrganic SynthesisC - H Bond FunctionalizationHeterocycle FunctionalizationNickel CatalysisNickel-catalyzed Cross-couplingTransition Metal-catalyzed Synthesis
A general method based on nickel-catalyzed C-O activation of various phenol derivatives with potassium (hetero)aryltrifluoroborates has been developed. A large number of heterobiaryls can be easily obtained with yields up to 99% using methanesulfonate cross-coupling partners.
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