RDX Binds to the GABA _A Receptor–Convulsant Site and Blocks GABA _A Receptor–Mediated Currents in the Amygdala: A Mechanism for RDX-Induced Seizures

Abstract

These results suggest that binding to the GABA(A) receptor convulsant site is the primary mechanism of seizure induction by RDX and that reduction of GABAergic inhibitory transmission in the amygdala is involved in the generation of RDX-induced seizures. Knowledge of the molecular site and the mechanism of RDX action with respect to seizure induction can guide therapeutic strategies, allow more accurate development of safe thresholds for exposures, and help prevent the development of new explosives or other munitions that could pose similar health risks.