REACTIONS OF CARBOHYDRATE DERIVATIVES DURING GAS–LIQUID CHROMATOGRAPHY

Abstract

The following reactions have been shown to occur during gas–liquid chromatography of carbohydrate derivatives: (a) deamidation, (b) change in size of the sugar ring, (c) rearrangement of acetal or ketal groups, (d) degradative rearrangement of acetylated amino sugars. The results emphasize that stability of a compound under conditions used in gas–liquid chromatography is a necessary prerequisite to the application of that technique; the precautions that should be followed to determine stability are indicated.