Estrogens increase the endothelial nitric oxide synthase (ecNOS) mRNA level in LNCaP human prostate carcinoma cells

Abstract

The results indicate that ecNOS mRNA expression in LNCaP-FGC can be induced by E2, but also by its prehormone E1S, probably after conversion to E2. However, the different stimulation patterns observed for E2 and E1S in LNCaP-FGC and LNCaP-r cells also could indicate stimulatory as well as inhibitory effects of estrogens in this model system, and this could depend on time of exposure and the concentration of active estrogen.