Publication | Open Access
Complete Sequences of Two Plasmids in a <i>bla</i> <sub>NDM-1</sub> -Positive Klebsiella oxytoca Isolate from Taiwan
64
Citations
20
References
2013
Year
Microbial PathogensKlebsiella PneumoniaeComplete SequencesAntibiotic ResistanceBacterial PathogensDrug ResistanceSequence AnnotationAntibacterial MechanismsInfection ControlActive InfectionAntimicrobial ResistanceHealth SciencesPathogen CharacterizationMolecular MicrobiologyBacterial ResistanceGenetic DeterminantsClinical MicrobiologyBiologyAntimicrobial Resistance GeneAntimicrobial SusceptibilityAntibioticsMicrobiologyMedicineMicrobial Genetics
Genetic determinants of a bla(NDM-1)-positive, multidrug-resistant bacterial isolate that caused active infection was investigated by DNA sequencing. Two plasmids, pKOX_NDM1 and pKOX-R1, were identified for the Klebsiella oxytoca strain E718. Sequence annotation revealed a bla(NDM-1) gene in pKOX_NDM1 and two extended-spectrum β-lactamase producers (bla(CTX-M-3) and blaSHV-12) and a wide array of resistance genes in pKOX-R1. These findings highlight the difficulty in treating multidrug-resistant bacterial infections and the potential danger of emerging resistant enterobacteria.
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