Decorin Accumulation Contributes to the Stromal Opacities Found in Congenital Stromal Corneal Dystrophy

Abstract

Accumulation of decorin was found in the interlamellar areas of amorphous substance. The truncated decorin is present in CSCD corneas, and there is evidence it may aggregate in vitro. Thus, decorin accumulation appears to contribute to the stromal opacities that are characteristic of CSCD.