International Journal of Radiation Biology and Related Studies in Physics Chemistry and Medicine · 1963 · 18 citations · 1 references
MedicineHematologyRadiation OncologyRadiation BiophysicsRadiation DosimetryRadiobiologyBiological Effects Of RadiationRadiation BiologyRadiation HealthRadiation PhysiologyRadiation TherapyRadiation ToxicityAcute Radiation InjuryLow-dose Ionizing RadiationLow-dose Radiation ResponsesRadiation Dose AssessmentRadiation Dose EffectsRadiation Effects On The Hematopoietic SystemRadiation-induced Hematopoietic InjuryRadiobiological Response
SummaryAfter irradiation, the amount of deoxyribopolynucleotides, i.e. substances soluble in 0·14 M solution of sodium chloride, insoluble in 0·2 M solution of perchloric acid and giving a positive reaction for deoxyribose with diphenylamine, increases in haematopoietic and lymphatic tissues of mice and rats. We have found that the increase is practically a linear function of the radiation dose ranging within 0–300 r. With the aid of this reaction, irradiation with a dose of 30–50 r, or contamination due to intraperitoneal administration of 5 mc 32P/kg body-weight, can be diagnosed. The authors believe that the determination of the level of deoxyribopolynucleotides could be used as an early indicator of acute radiation lesions due to small and medium radiation doses.
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