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Synthesis of 2-Amino-3-ethoxycarbonylpyrroles
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1987
Year
EngineeringSelective N-methylationOrganic ChemistryPhase-transfer ConditionsStereoselective SynthesisChemistryVersatile RouteSynthetic ChemistryEnantioselective SynthesisBiomolecular Engineering
Condensation of ethoxycarbonylacetamidine with α-bromoketones affords a versatile route to 2-amino-3-ethoxycarbonylpyrroles. Selective N-methylation is achieved under phase-transfer conditions.