A Cytotoxic Xanthone Dimer from the Entomopathogenic Fungus <i>Aschersonia</i> sp. BCC 8401

Abstract

Ascherxanthone A (1), a novel symmetrical tetrahydroxanthone dimer, was isolated from the entomopathogenic fungus Aschersonia sp. BCC 8401. The structure of 1 was elucidated by spectroscopic analysis, especially 2D-NMR. Compound 1 exhibited activity against Plasmodium falciparum K1 with an IC(50) value of 0.20 microg/mL, but it also showed cytotoxic activities against Vero cells and three tumor cell lines.