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Preparation of 3-Alkyl-Oxindoles by Copper(II)-Mediated C-H, Ar-H Coupling Followed by Decarboxyalkylation
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2010
Year
Chemical EngineeringMedicinal ChemistryEngineeringCross-coupling ReactionBiochemistryCyclization ProcessNatural SciencesNovel OrganocatalystsSitu N-deprotectionOrganic ChemistryOrganometallic CatalysisCatalysisChemistryAr-h Coupling FollowedHeterocycle ChemistryTelescoped VariantInorganic Synthesis
A novel route for the conversion of anilides into 3-alkyl-oxindoles is described in which a copper(II)-mediated cyclization process is followed by an acid-mediated decarboxyalkylation. Scope and limitation studies are reported together with a telescoped variant which incorporates in situ N-deprotection.