Human Infant Respiratory Syncytial Virus (RSV)–Specific Type 1 and 2 Cytokine Responses Ex Vivo during Primary RSV Infection

Abstract

During primary RSV infection, many infants demonstrated RSV-specific IFN- gamma responses. The strongest IL-4 and IL-5 responses were detected in 3 infants with severe disease, suggesting that type 2 responses may contribute to the pathogenesis of severe disease.