Concepedia

Assessment of Pulmonary Neutrophilic Inflammation in Emphysema by Quantitative Positron Emission Tomography

Deepak Subramanian, Lee Jenkins, Ross Edgar, Nabil Quraishi, Robert A. Stockley, David Parr

American Journal of Respiratory and Critical Care Medicine · 2012 · 69 citations · 29 references

DOI

Abstract

Quantitative (18)FDG PET-CT has a potential role as an imaging biomarker in mechanistic and interventional studies in patients with usual COPD. The data support previous evidence of distinct functional characteristics of neutrophils in COPD. Clinical trial registered with https://eudract.ema.europa.eu/index.html (EudraCT 2007-004869-18).

References

29

Chronic obstructive pulmonary disease: current burden and future projections

Alan D López, Kenji Shibuya, Chalapati Rao et al. · European Respiratory Journal · 2006 · 1.3K citations · Full text

Using the lower limit of normal for the FEV1/FVC ratio reduces the misclassification of airway obstruction

MP Swanney, Gregg L Ruppel, Paul Enright et al. · Thorax · 2008 · 530 citations · Full text

Tumor necrosis factor-alpha levels and weight loss in chronic obstructive pulmonary disease.

M Di Francia, D. Barbier, Jean Louis Mège et al. · American Journal of Respiratory and Critical Care Medicine · 1994 · 482 citations

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Tumor Necrosis Factor-α Drives 70% of Cigarette Smoke–induced Emphysema in the Mouse

Andrew Churg, Rong D. Wang, Hsin Tai et al. · American Journal of Respiratory and Critical Care Medicine · 2004 · 340 citations

Enhanced neutrophil response in chronic obstructive pulmonary disease

Thorax · 2001 · 244 citations · Full text