Transplantation · 2014 · 57 citations · 19 references
Genetic mutations of the complement alternative pathway were confirmed in half of our patients, most of those mutations are in CHF. We demonstrate that treatment or prophylaxis with eculizumab was effective in reversing or preventing aHUS whether or not genetic complement mutations were identified.
19
Terminal Complement Inhibitor Eculizumab in Atypical Hemolytic–Uremic Syndrome
Christophe Legendre, Christoph Licht, Petra Muus et al. · New England Journal of Medicine · 2013 · 1.5K citations · Full text