A versatile polypeptoid platform based on N-allyl glycine

Abstract

N-Allyl glycine N-carboxyanhydride (NCA) was synthesized and polymerized by ring opening polymerization under homo- or heterophase conditions to afford well-defined polypeptoids (M(W) = 1.5-10.5 kg mol(-1), PDI = 1.1-1.4). Poly(N-allyl glycine) demonstrated stimuli-responsive behaviour in water and was readily modified via thiol-ene photochemistry under experimentally benign conditions.