Copper‐Catalyzed Domino S_N2′/Coupling Reaction: A Versatile and Facile Synthesis of Cyclic Compounds from Baylis–Hillman Acetates

Abstract

Abstract A variety of substituted quinoline/pyridine, thiochromene and naphthalene derivatives, which might be of biological and medicinal value, were synthesized by copper‐catalyzed domino S N 2′/coupling, S N 2′/deacylation/coupling and S N 2′/coupling/elimination reactions. The method provides a general and convenient approach to the synthesis of various substituted cyclic compounds from the corresponding Baylis–Hillman (B‐H) acetates and N‐/S‐/C‐nucleophiles.