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EFFECT OF OXYGEN TENSION AND CERTAIN CHEMICALS ON THE X-RAY SENSITIVITY OF MUTATION PRODUCTION AND SURVIVAL
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1951
Year
EngineeringGeneticsRadiation EffectRadiation ExposureCellular PhysiologyRedox BiologyX-ray FluorescenceOxidative StressX-ray SensitivityRadiation OncologyNuclear MedicineRadiologyLiving CellsCell DivisionRadiation ApplicationOxygen TensionCell BiologyGenetic EngineeringMedicineMutagenesis
The effect of oxygen tension on the X-ray sensitivity of living cells was recognized as long as 30 years ago (Holthusen, 1921). It is only in the last few years that greater attention has been paid to this problem. Several reviews have appeared, e.g., (Bacq, 1951; Gray, 1951), describing the earlier development of this work and it is superfluous to go over the details of these findings. This paper will deal only with some of the work which has come out during the last two or three years together with some work which has not yet been published. The major part of this discussion will deal with the effect of oxygen tension on X-ray sensitivity as measured by the lethal effects, chromosome changes, and mutations. The latter part of the paper will be concerned with the effects of chemicals on X-ray sensitivity, a problem which is closely integrated with...