A highly efficient tandem [3 + 2] “click” cycloaddition/6-<i>exo</i>-cyclization strategy for the construction of triazole fused pyrazines

Abstract

The pharmaceutically important tetrahydro-[1,2,3]triazolopyrazine heterocyclic architecture has been synthesized <italic>via</italic> a concise tandem “click”/6-<italic>exo</italic>-dig cyclization strategy under mild conditions in mixed aqueous–organic media.