Particle Size Analysis of Aerosols from Medicinal Inhalers

Abstract

Methods currently in use for the in-vitro measurement of the particle size distribution of aerosols from medical inhalers are reviewed with emphasis on their applicability both for product development and quality control testing and for simulation of likely performance in clinical use. Key attributes and limitations of the various techniques are identified, and consideration is also given both to likely developments to improve the capabilities of these analyzers as well as to the procedures for their use.