COMPOUND 48/80: A POTENT HISTAMINE LIBERATOR

Abstract

Baltzly, Buck, de Beer, and Webb (1949), analysing the depressor action of certain isoquinoline derivatives, found that this action was due to contamination with phenylethylamine condensation products. Several such compounds were pre- pared, and one of them (Compound 48/80) was found to lower the dog's blood- pfessure in very small doses. Compound 48/80 was obtained from the condensa- tion of p-methoxyphenethyl-methylamine with formaldehyde, and has a structure of the general type: NHCH3