Enantioselective Organocatalytic Partial Transfer Hydrogenation of Lactone-Fused Quinolines

Abstract

The first enantioselective synthesis of 4-aza-podophyllotoxin derivatives by partial transfer hydrogenation of lactone-fused quinolines was achieved using a chiral Brønsted acid catalyst. This reaction was extended to a large scope of substrates with good yields and enantioselectivities.