Bioscience Biotechnology and Biochemistry · 2014 · 18 citations · 12 references
MedicineMedicinal ChemistryPharmacologyAntimicrobial PharmacologyChemotherapyDrug DiscoveryAntiparasitic AgentsAntiparasitic ChemotherapyAntiparasitic PharmacologyAntiparasitic PharmacotherapyAntiparasitic TherapyAntimalarial AgentsAntimalarial ChemotherapyAntimalarial Drug DevelopmentChemotherapy Of MalariaMalaria ParasitesPlasmodium FalciparumTreatment Of Malaria
Quinomycin A and its derivatives were identified as potent antimalarial (Plasmodium falciparum) agents in a screen of the RIKEN NPDepo chemical library. IC50 values of quinomycin A and UK-63,598 were approximately 100 times lower than that of the antimalarial drug chloroquine. This activity was mitigated by the addition of plasmid DNA, suggesting that these compounds act against parasites by intercalating into their DNA.
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Human Malaria Parasites in Continuous Culture
William Trager, James B. Jensen · Science · 1976 · 8K citations
Thousands of chemical starting points for antimalarial lead identification
Francisco‐Javier Gamo, Laura M. Sanz, Jaume Vidal et al. · Nature · 2010 · 1K citations