Alterations in the expression pattern of MTHFR, DHFR, TYMS, and SLC19A1 genes after treatment of laryngeal cancer cells with high and low doses of methotrexate

A miR-24 microRNA binding-site polymorphism in dihydrofolate reductase gene leads to methotrexate resistance

Prasun Mishra, Rita Humeniuk, Pravin J. Mishra et al. · Proceedings of the National Academy of Sciences · 2007 · 417 citations · Full text

Life Sciences, Genetics, Molecular Biology +14

Mechanisms of methotrexate resistance in osteosarcoma.

Wei Guo, John H. Healey, Paul A. Meyers et al. · PubMed · 1999 · 154 citations

Medicine, Molecular Genetics, Oncology +15

Thymidylate synthase: a novel genetic determinant of plasma homocysteine and folate levels

Binh N. Trinh, Choon Nam Ong, Gerhard A. Coetzee et al. · Human Genetics · 2002 · 140 citations

Life Sciences, Genetics, Molecular Genetics +14

Results of a randomised phase II study comparing docetaxel with methotrexate in patients with recurrent head and neck cancer

Emmanuel Guardiola, Frédéric Peyrade, L. Chaigneau et al. · European Journal of Cancer · 2004 · 118 citations

Medicine, Oncology, Chemotherapy +4

Folate Deficiency Induces Genomic Uracil Misincorporation and Hypomethylation But Does Not Increase DNA Point Mutations

Heinz Linhart, Aron M. Troen, George W. Bell et al. · Gastroenterology · 2008 · 99 citations · Full text

Life Sciences, Genetics, Molecular Biology +10