A Case of White Sponge Nevus-like Lesion of the Oral Mucosa Successfully Treated with Azithromycin.

Abstract

A 30-year-old Japanese man presented white spongy plaques on his buccal mucosa and lower lip. The surface of the lesion showed irregular and small portions of the plaques were desquamative. Histopathologically, stratified squamous epithelium characterized by acanthosis and parakeratosis of surface layer was identified. Marked intracellular edema without spongiosis and vacuolated spinous cells were observed. Topical steroid and laser treatment were not effective, but the lesion disappeared completely after treatment with azithromycin.