Concepedia

Structure–Activity Study of l-Cysteine-Based N-Type Calcium Channel Blockers: Optimization of N- and C-Terminal Substituents

Takuya Seko, Masashi Kato, Hiroshi Kohno, Shizuka Ono, Kazuya Hashimura, Hideyuki Takimizu, Katsuhiko Nakai, Hitoshi Maegawa, Nobuo Katsube, Masaaki Toda

Bioorganic & Medicinal Chemistry Letters · 2002 · 20 citations · 7 references

DOIFull text

Open access

Concepts

References

7

Synthesis of a Series of 4-Benzyloxyaniline Analogues as Neuronal N-Type Calcium Channel Blockers with Improved Anticonvulsant and Analgesic Properties

Lain‐Yen Hu, Todd R. Ryder, Michael Rafferty et al. · Journal of Medicinal Chemistry · 1999 · 41 citations · Full text

, , +15

N-type calcium channel blockers in pain and stroke

Brian J. Cox, Jane Denyer · Expert Opinion on Therapeutic Patents · 1998 · 32 citations · Full text

, , +16

The discovery of [1-(4-dimethylamino-benzyl)-piperidin-4-yl]-[4-(3,3-dimethylbutyl)-phenyl]-(3-methyl-but-2-enyl)-amine, an N-type Ca+2 channel blocker with oral activity for analgesia

Lain‐Yen Hu, Todd R. Ryder, Michael Rafferty et al. · Bioorganic & Medicinal Chemistry · 2000 · 29 citations

, , +10

(<i>S</i>)-4-Methyl-2-(methylamino)pentanoic Acid [4,4-Bis(4-fluorophenyl)butyl]amide Hydrochloride, a Novel Calcium Channel Antagonist, Is Efficacious in Several Animal Models of Pain

Yuntao Song, S. Scott Bowersox, David T. Connor et al. · Journal of Medicinal Chemistry · 2000 · 21 citations · Full text

, , +9

SNX-111

S. Scott Bowersox, N. Tich, Martha Mayo et al. · Drugs of the Future · 1998 · 20 citations