Lexipafant (BB-882), a platelet activating factor receptor antagonist, ameliorates mucosal inflammation in an animal model of colitis - Concepedia

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Lexipafant (BB-882), a platelet activating factor receptor antagonist, ameliorates mucosal inflammation in an animal model of colitis

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References

1996

Year

John Meenan, Tim A. Grool, Daan W. Hommes, Sophie Dijkhuizen, Fibo J. ten Kate, Michael L. Wood, Michael R. Whittaker, Guido N.J. Tytgat, S J van Deventer

European Journal of Gastroenterology & Hepatology

Abstract

The PAF receptor antagonist BB-882 shows efficacy in treating inflammation in an animal model of acute colitis as evidenced by a dose-dependent fall in macroscopic mucosal damage, neutrophil infiltration and reduced generation of inflammatory mediators.