Effectiveness of Antidepressant Drugs: A Triple-Blind Study Comparing Imipramine, Desipramine, and Placebo

Abstract

The authors made a triple-blind comparison of placebo, imipramine, and desipramine in severely depressed hospitalized psychiatric patients. They found that both drugs were superior to placebo, that imipramine was the drug of choice in treating these patients, and that imipramine was superior to desipramine and placebo in the rapidity of action and in the degree of improvement noted.