Treatment of Myelodysplasia in a Patient with Active Rheumatoid Arthritis

Abstract

Letters7 November 2000Treatment of Myelodysplasia in a Patient with Active Rheumatoid ArthritisAlan J. Birnbaum, MD and Patrick Gentile, MDAlan J. Birnbaum, MDSouth Bend Clinic; South Bend, IN 46617 (Birnbaum, Gentile)Search for more papers by this author and Patrick Gentile, MDSouth Bend Clinic; South Bend, IN 46617 (Birnbaum, Gentile)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-133-9-200011070-00037 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:We describe a patient with the myelodysplastic syndrome in whom anemia resolved and bone marrow structure returned to normal after etanercept treatment.The patient is a 54-year-old woman with an 11-year history of rheumatoid arthritis. Previous treatment with prednisone (≤ 7.5 mg/d) and hydroxychloroquine controlled her arthritis. Her baseline complete blood count had shown mild anemia of chronic disease, with a hemoglobin level of 100 to 110 g/L.In August 1998, the patient reported shortness of breath, and her hemoglobin level was 61 g/L. Leukocyte and platelet counts were normal. Two independent bone marrow samples revealed myelodysplasia ...References1. Selleri C, Sato T, Anderson S, Young NS, Maciejewski JP. Interferon-γ and tumor necrosis factor-α suppress both early and late stages of hematopoiesis and induce programmed cell death. J Cell Physiol. 1995;165:538-46. CrossrefMedlineGoogle Scholar2. Udupa KB, Sharma BG. Possible role of tumor necrosis factor-α in erythropoietic suppression by endotoxin and granulocyte/macrophage colony-stimulating factor. Am J Hematol. 1996;52:178-83. CrossrefMedlineGoogle Scholar3. Shetty V, Mundle S, Alvi S, Showel M, Broady-Robinson L, Dar S, et al . Measurement of apoptosis, proliferation and three cytokines in 46 patients with myelodysplastic syndromes. Leuk Res. 1996;20:891-900. CrossrefMedlineGoogle Scholar4. Winter SS, Hanissian GA, Harville TO, Ware RE. Tumor necrosis factor-α suppresses hematopoiesis in children with myelodysplasia. Med Pediatr Oncol. 1997;28:69-74. CrossrefMedlineGoogle Scholar5. Heaney ML, Golde DW. Myelodysplasia. N Engl J Med. 1999;340:1649-60. CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAuthors: Alan J. Birnbaum, MD; Patrick Gentile, MDAffiliations: South Bend Clinic; South Bend, IN 46617 (Birnbaum, Gentile) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 7 November 2000Volume 133, Issue 9Page: 753-754KeywordsAnemiaArthritisBone marrowHematopoiesisHemoglobinMyelodysplastic syndromesPlateletsRheumatoid arthritisSplenomegalyTumor necrosis factor ePublished: 7 November 2000 Issue Published: 7 November 2000 Copyright & PermissionsCopyright © 2000 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...