Journal of Medicinal Chemistry · 1978 · 59 citations · 0 references
MedicineMicrobiologyPharmacologyAntimicrobial PharmacologyMedical MicrobiologyMycologyAntifungal AgentsAntifungal PharmacologyAntifungal PharmacotherapyAntifungal TherapyFungal InfectionsFungal PathogenesisAntifungal TreatmentsCandida TherapyFungal Infection TreatmentNew Antifungal AgentsNovel Antifungal Drug DevelopmentProtection Against ReinfectionReinfection DynamicsReinfection Studies
The preparation and antifungal properties of 1-[4-(4-chlorophenyl)-2-(2,6-dichlorophenylthio)-n-butyl]-1H-imidazole nitrate 1 are described. It is particularly effective against in vivo Candida albicans infections (mice), maintaining good activity down to 0.25% formulation strength and showing unusually low reinfection rates after treatment is ended.