Taxol producing mangrove endophytic fungi Fusarium oxysporum from Rhizophora annamalayana

Abstract

To find out the anticancer properties of Taxol (paclitaxel) isolated from mangrove endophytic fungi. An endophytic fungus Fusarium oxysporum was isolated from Rhizophora annamalayana, a mangrove plant and analysis for Taxol production. The fungus was identified based on morphology and spore characteristics. The secondary metabolites Taxol were extracted with ethyl acetate. Taxol extracted was characterized by chromatographic and spectrometric analysis. Thin layer chromatography plate shows violet red and IR spectrum values were conformed as group of terpenoid functional groups. The HPLC analysis showed the higher yield of Taxol 172.3 μg/L from potato dextrose liquid medium. The bioprospecting of entophytic fungus F. oxysporum isolated from mangrove is discussed and may serve as a potential material for the production of Taxol for anticancer treatment.