Biotransformation of Drugs: Quantitative Structure–Activity Relationships for Barbiturates, Tertiary Amines, and Substituted Imidazoles

Enzymatic Metabolism of Drugs and other Foreign Compounds

B.B. Brodie, James R. Gillette, Bert N. La Du · Annual Review of Biochemistry · 1958 · 502 citations

Life Sciences, Biochemistry, Biology +14

Relationship between the lipid solubility of drugs and their oxidation by liver microsomes

Leo E. Gaudette, B.B. Brodie · Biochemical Pharmacology · 1959 · 151 citations

Pharmacy, Biochemistry, Pharmacology +14

Imidazole derivatives—A new class of microsomal enzyme inhibitors

C.F. Wilkinson, Krystyna Hetnarski, Tobias O. Yellin · Biochemical Pharmacology · 1972 · 130 citations

Medicine, Medicinal Chemistry, Pharmacology +11

Quantitative Relationships Between Lipophilic Character and Drug Metabolism

Corwin Hansch · Drug Metabolism Reviews · 1972 · 110 citations

Pharmacy, Pharmacokinetics, Pharmacology +12

Structure-activity correlations in the metabolism of drugs

Corwin Hansch, Eric J. Lien, Friederike Helmer · Archives of Biochemistry and Biophysics · 1968 · 69 citations

Pharmacy, Medicinal Chemistry, Pharmacology +12