Targeting both IGF-1R and mTOR synergistically inhibits growth of renal cell carcinoma in vitro

Abstract

Both Hex-hR1 and 1R-2b proved to be more potent than parental hR1 in inhibiting growth of RCC in vitro. Synergy was achieved when each of the three hR1-based agents was combined with temsirolimus, suggesting a new approach for treating RCC.