Therapeutic inhibition of fatty acid oxidation in right ventricular hypertrophy: exploiting Randle’s cycle

The Antianginal Drug Trimetazidine Shifts Cardiac Energy Metabolism From Fatty Acid Oxidation to Glucose Oxidation by Inhibiting Mitochondrial Long-Chain 3-Ketoacyl Coenzyme A Thiolase

Paul F. Kantor, Arnaud Lucien, Raymond Kozak et al. · Circulation Research · 2000 · 807 citations

Medicine, Cardiology, Pharmacology +17

Pharmacologic inhibition of fatty acid oxidation sensitizes human leukemia cells to apoptosis induction

Ismael Samudio, Romain Harmancey, Michael Fiegl et al. · Journal of Clinical Investigation · 2009 · 699 citations · Full text

Life Sciences, Cell Biology, Pharmacology +17

Electrophysiological Effects of Ranolazine, a Novel Antianginal Agent With Antiarrhythmic Properties

Charles Antzelevitch, Luiz Belardinelli, Andrew C. Zygmunt et al. · Circulation · 2004 · 678 citations · Full text

Medicine, Cardiology, Pharmacology +17

Chronic Pulmonary Artery Pressure Elevation Is Insufficient to Explain Right Heart Failure

Harm Jan Bogaard, Ramesh Natarajan, Scott C. Henderson et al. · Circulation · 2009 · 509 citations · Full text

Medicine, Cardiology, Physiology +16

The inhibition of pyruvate dehydrogenase kinase improves impaired cardiac function and electrical remodeling in two models of right ventricular hypertrophy: resuscitating the hibernating right ventricle

Lin Piao, Yong-Hu Fang, Virgilio J. J. Cadete et al. · Journal of Molecular Medicine · 2009 · 323 citations

Life Sciences, Cardiology, Physiology +17