Nucleotide Formation as a Determinant of 5-Fluorouracil Response in Mouse Leukemias

Abstract

Survival of mice bearing different transplantable leukemias and treated with 5-fluorouracil was compared with accumulation of drug nucleotides in vitro. There was significant correlation,suggesting that cellular capacity for conversion of the drug to nucleotides is a major determinant of inherent drug sensitivity of these leukemias.