Toxic cardiac effects of catecholamines: role of β-adrenoceptor downregulation

Effect of metoprolol CR/XL in chronic heart failure: Metoprolol CR/XL Randomised Intervention Trial in-Congestive Heart Failure (MERIT-HF)

The Lancet · 1999 · 5.1K citations

Heart Failure, Chronic Heart Failure, Cardiovascular Disease +7

The Cardiac Insufficiency Bisoprolol Study II (CIBIS-II): a randomised trial

The Lancet · 1999 · 4.9K citations

Heart Failure, Cardiovascular Disease, Randomised Trial +9

Beta 1- and beta 2-adrenergic-receptor subpopulations in nonfailing and failing human ventricular myocardium: coupling of both receptor subtypes to muscle contraction and selective beta 1-receptor down-regulation in heart failure.

Michael R. Bristow, Robert Ginsburg, Victor A. Umans et al. · Circulation Research · 1986 · 1.3K citations · Full text

Cardiac Muscle, Cardiomyopathy, Heart Failure +13

Myocardial infarct size and ventricular function in rats.

Marc A. Pfeffer, J M Pfeffer, Michael C. Fishbein et al. · Circulation Research · 1979 · 1.3K citations

Hypertension, Heart Failure, Cardiovascular Function +17

Altered expression of beta-adrenergic receptor kinase and beta 1-adrenergic receptors in the failing human heart.

Martin Ungerer, Michael Böhm, John S. Elce et al. · Circulation · 1993 · 875 citations · Full text