Neonatal Tetany

Abstract

Case Studies1 December 1964Neonatal TetanyDiagnostic Lead to Hyperparathyroidism in the MotherPETER HUTGHIN, M.D., DAVID M. KESSNER, M.D.PETER HUTGHIN, M.D., DAVID M. KESSNER, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-61-6-1109 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptSince Von Recklinghausen's description of generalized osteitis fibrosa cystica, the clinical manifestations of hyperparathyroidism have undergone an apparent change. After early recognition of the renal complications of the disease (1), a variety of other manifestations of primary hyperparathyroidism were noted, including peptic ulcer (2), pancreatitis (3), multiple endocrine adenomata (4), pitressin resistant diabetes insipidus (5), and various psychologic manifestations (6). Patients with a classical picture of bone or renal disease have gradually become less common, whereas patients without these characteristic findings have been diagnosed more frequently (7). Indeed, in some the diagnosis has been arrived at only by serendipity (8)....References1. ALBRIGHTBAIRDCOPEBLOOMBERG FPCOE: Studies on the physiology of the parathyroid glands. IV. Renal complications of hyperparathyroidism. Amer. J. Med. Sci. 187: 49, 1934. CrossrefGoogle Scholar2. KIRSNER JB: The parathyroids and peptic ulcer. Gastroenterologia 34: 145, 1958. CrossrefGoogle Scholar3. COPECULVERMEXTERNARDIN OPJCGGL: Pancreatitis, a diagnostic clue to hyperparathyroidism. Ann. Surg. 145: 857, 1957. CrossrefMedlineGoogle Scholar4. UNDERDAHLWOOLNERBLACK LOLBBM: Multiple endocrine adenomas. J. Clin. Endocr. 13: 20, 1953. CrossrefMedlineGoogle Scholar5. ALDIS AS: Clinical experiences of lesser known manifestations of hyperparathyroidism. Proc. Roy. Soc. Med. 54: 489, 1961. CrossrefMedlineGoogle Scholar6. KEYNES WM: The symptoms of hyperparathyroidism. Brit. Med. J. 1: 239, 1961. CrossrefMedlineGoogle Scholar7. PEARLSTERNBERGDINGMAN MAWHJF: Unusual case of hyperparathyroidism. Arch. Intern. Med. (Chicago) 110: 481, 1962. CrossrefMedlineGoogle Scholar8. RANDALKEATING RVFR: Serendipity in the diagnosis of primary hyperparathyroidism. Trans. Ass. Amer. Physicians 71: 77, 1958. MedlineGoogle Scholar9. LUDWIG GD: Hyperparathyroidism in relation to pregnancy. New Eng. J. Med. 267: 637, 1962. CrossrefMedlineGoogle Scholar10. RIDDICKREISS FAE: Hyperparathyroidism. Ann. Intern. Med. 56: 183, 1962. LinkGoogle Scholar11. MUNSONHIRSCHTASHJIAN PLPFAH: Parathyroid gland. Ann. Rev. Physiol. 25: 325, 1963. CrossrefMedlineGoogle Scholar12. KEATING FR: Diagnosis of primary hyperparathyroidism. JAMA 178: 547, 1961. CrossrefMedlineGoogle Scholar13. MCGEOWNMORRISON MGE: Hyperparathyroidism. Postgrad. Med. J. 35: 330, 1959. CrossrefMedlineGoogle Scholar14. MULLBILL JWAH: Variations in serum calcium and phosphorus during pregnancy. Amer. J. Obstet. Gynec. 27: 510, 1934. CrossrefGoogle Scholar15. BODANSKYDUFF MVB: Regulation of the level of calcium in the serum during pregnancy. JAMA 112: 223, 1939. CrossrefGoogle Scholar16. GOSS DA: Renal conservation of calcium during pregnancy. Obstet. Gynec. 20: 199, 1962. Google Scholar17. MULL JW: Variations in serum calcium and phosphorus during pregnancy. IV. Effect on the body stores as shown by the ash of rats. J. Clin. Invest. 15: 515, 1936. CrossrefMedlineGoogle Scholar18. ANDERSCHOBERST MFW: Filterable serum calcium in late pregnancy and parturient women, and in the newborn. Ibid., p. 131. Google Scholar19. MACK HC: The plasma proteins. Clin. Obstet. Gynec. 3: 336, 1960. CrossrefGoogle Scholar20. MILLERDAVISKINGHUGGINS GHMEAGCB: Serum proteins in pregnancy. J. Lab. Clin. Med. 37: 538, 1951. MedlineGoogle Scholar21. CORYELLBEACHROBINSONMACYMACK MNEFARIGHC: Metabolism of women during the productive cycle. XVII. Changes in electrophoretic patterns of plasma proteins throughout the cycle and following delivery. J. Clin. Invest. 29: 1559, 1950. CrossrefMedlineGoogle Scholar22. BOKELMANBOCK OA: Uber die zustandsform des calcium in serum wahrend der gestationszeit. II. Die beziehungen zwischen mutter und fetus. Arch. Gynaek. 133: 739, 1928. CrossrefGoogle Scholar23. COMAR CL: Radiocalcium studies in pregnancy. Ann. N. Y. Acad. Sci. 64: 281, 1956. CrossrefGoogle Scholar24. SINCLAIR JG: Fetal rat parathyroids as affected by changes in maternal serum calcium and phosphorus through parathyroidectomy and dietary control. J. Nutr. 23: 141, 1942. CrossrefGoogle Scholar25. WALTON RL: Neonatal tetany in two siblings: effect of maternal hyperparathyroidism. Pediatrics 13: 227, 1954. MedlineGoogle Scholar26. BAKWIN H: Pathogenesis of tetany of the newborn. Amer. J. Dis. Child. 54: 1211, 1937. Google Scholar27. BAKWIN H: Tetany in newborn infants: relation to physiologic hypoparathyroidism. J. Pediat. 14: 1, 1939. CrossrefGoogle Scholar28. CONNELLYCRAWFORDWATSON JPJDJ: Studies of neonatal hyperphosphatemia. Pediatrics 30: 425, 1962. MedlineGoogle Scholar29. DODDRAPAPORT KS: Hypocalcemia in the neonatal period. Amer. J. Dis. Child. 78: 537, 1949. CrossrefMedlineGoogle Scholar30. TALBOTSOBELMCARTHURCRAWFORD NBEHJWJD: Functional Endocrinology from Birth Through Adolescence. Harvard University Press, Cambridge, 1952, p. 118. Google Scholar31. VAN ARSDEL PP: Maternal hyperparathyroidism as a cause of neonatal tetany. J. Clin. Endocr. 15: 680, 1955. CrossrefGoogle Scholar32. BUCHS S: Angeborener hypoparathyreoidismus von drei brudern infolge von hyperparathyreoidismus der mutter. Schweiz. Med. Wschr. 91: 660, 1961. Google Scholar33. MCGEOWNFIELD MGCM: Asymptomatic hyperparathyroidism. Lancet 2: 1268, 1960. CrossrefMedlineGoogle Scholar34. DITTMER DS Blood and Other Body Fluids. Edited by Federation of American Society of Experimental Biologists, Washington, D. C., 1961. Google Scholar35. BRUCESTRONG JJA: Maternal hyperparathyroidism and parathyroid deficiency in the child. Quart. J. Med. 24: 307, 1955. MedlineGoogle Scholar36. FRIDRICHSEN C: Tetany in a suckling. Lancet 1: 85, 1939. CrossrefGoogle Scholar37. HUNTERTURNBULL DHM: Hyperparathyroidism: generalized osteitis fibrosa. Brit. J. Surg. 19: 203, 1931. CrossrefGoogle Scholar38. WALTON AJ: Surgical treatment of parathyroid tumours. Ibid., p. 285. Google Scholar39. GARLOCK JH: Differential diagnosis of hyperparathyroidism. Amer. Surg. 108: 347, 1938. Google Scholar40. FROHNERWOLGAMOT RNJC: Primary hyperparathyroidism: five cases in one family. Ann. Intern. Med. 40: 765, 1954. LinkGoogle Scholar41. LEHRKRUKOWSKI DM: Protection by pregnancy against the sequelae of acute hyperparathyroidism. Naunyn Schmiedeberg Arch. Exp. Path. 242: 143, 1961. CrossrefGoogle Scholar42. PETITCLARK DWRL: Hyperparathyroidism and pregnancy. Amer. J. Surg. 74: 860, 1947. CrossrefMedlineGoogle Scholar43. WHALLEY PJ: Hyperparathyroidism and pregnancy. Amer. J. Obstet. Gynec. 86: 517, 1963. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: New Haven, ConnecticutFrom the Departments of Surgery and Medicine, Yale University School of Medicine, New Haven, Conn.Requests for reprints should be addressed to David Kessner, M.D., Department of Medicine, Yale University School of Medicine, 333 Cedar Street, New Haven, Conn. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byAcute PancreatitisHypocalcemic tetany in the newborn as a manifestation of unrecognized maternal primary hyperparathyroidismLife-Threatening Hypercalcemia Associated With Primary Hyperparathyroidism During Pregnancy: Case Report And Review Of LiteraturePrimary Hyperparathyroidism During PregnancyEndocrine PathologyEndocrine Pathology in PaediatricsLate-onset hypocalcemia, rickets, and hypoparathyroidism in an infant of a mother with hyperparathyroidismEndocrine Regulation of Calcium Homeostasis During PregnancyEndocrine Pathology in PaediatricsMetabolic Bone Disease in ChildrenALTERED VITAMIN-D METABOLISM IN PREGNANCYHyperparathyroidism during pregnancyCalcium metabolism in pregnancy: A reviewNeonatal parathyroid function: Role of gestational age and postnatal ageSERUM IONIC CALCIUM LEVELS DURING PREGNANCYDisorders of the Endocrine SystemThe Clinical Problem of Primary HyperparathyroidismHypoparathyreoidismus im KindesalterA case of acute hyperparathyroidism, with thyrotoxicosis and pancreatitis, presenting as hyperemesis gravidarum.MATERNAL MALABSORPTION PRESENTING AS CONGENITAL RICKETSTABLET IDENTIFICATIONHYPOCALCÆMIC FITS IN NEONATESRecent advances in medicine for newborn infantsSome Aspects of Endocrinology in the Fetus and the NewbornTetany of the Newborn Associated with Maternal Parathyroid Adenoma 1 December 1964Volume 61, Issue 6Page: 1109-1115KeywordsAttentionCalciumHyperparathyroidismInfantsIngestionPancreatitisPeptic ulcersRenal diseasesSurgeryVasopressin ePublished: 1 December 2008 Issue Published: 1 December 1964 PDF downloadLoading ...