Synthetic Communications · 2001 · 40 citations · 15 references
Natural SciencesChemistryMedicinal ChemistryDrug DiscoveryReaction EngineeringSynthetic Medicinal ChemistrySafer Chemical SynthesisSulfur ChemistryDeprotection StrategyPyridine ChemistryPyridine Synthesis
Abstract Convenient deprotection of various pyridine-2-sulfonamides prepared by sulfonylation of primary and secondary amines with pyridine-2-sulfonylchloride was achieved by magnesium in methanol at 0°C to the corresponding amines in good yield. ACKNOWLEDGMENT We thank for financial support of Ministry of Science and Technology and helpful comments of Dr. Dennis Jackman (Bayer, Kansas City).
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Cleavage of sulfonamides with sodium naphthalene
Sungchul Ji, Leon B. Gortler, Anita J. Waring et al. · Journal of the American Chemical Society · 1967 · 157 citations