Exon 1 donor splice site mutations in the porphobilinogen deaminase gene in the non-erythroid variant form of acute intermittent porphyria

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

Mark A. Bradford · Analytical Biochemistry · 1976 · 225.4K citations

Life Sciences, Biochemistry, Protein Biochemistry +7

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

Analytical Biochemistry · 1987 · 63.3K citations

Life Sciences, Biochemistry, Molecular Biology +12

Prediction of human mRNA donor and acceptor sites from the DNA sequence

Søren Brunak, Jacob Engelbrecht, Steen Knudsen · Journal of Molecular Biology · 1991 · 806 citations

Life Sciences, Bioinformatics, Molecular Biology +12

[16] Splice junctions, branch point sites, and exons: Sequence statistics, identification, and applications to genome project

Periannan Senapathy, Marvin B. Shapiro, Nomi L. Harris · Methods in enzymology on CD-ROM/Methods in enzymology · 1990 · 686 citations

Life Sciences, Bioinformatics, Genetics +14

Intermittent Acute Porphyria — Demonstration of a Genetic Defect in Porphobilinogen Metabolism

Urs Meyer, Lars Strand, M. Doss et al. · New England Journal of Medicine · 1972 · 217 citations

Life Sciences, Genetics, Molecular Genetics +10